Effects of a New Oral Contraceptive Containing Ethinyl Estradiol and Desogestrel on Plasma Lipoproteins and Apolipoproteins
作者： W. März , C. Jung-Hoffmann , R. Siekmeier , H. Kuhl , W. Gross
DOI: 10.1007/978-3-642-84855-1_17
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摘要: The effect of a new two phase oral contraceptive containing ethinyl estradiol (EE) and desogestrel (DG) (40 μg EE + 24 DG for 7 days, 30 +125 DG) on plasma lipoproteins apolipoproteins has been studied in 19 healthy women. After an initial control cycle, the EE/DG combination was administered six months, aijd study completed with final washout cycle. lead to increases total triglycerides, very low density lipoproteins, high lipoproteins. HDL3-cholesterol increased significantly, whereas not affected. Apolipoproteins A-I, A-II, B increased. While both cholesterol triglyce-rides intermediate increased, there 20% decrease apoE. Apolipoprotein (a) decreased by 9% 24% after one three months treatment, respectively. It reverted baseline levels sixth treatment even wash out
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