In vitro anti-Helicobacter pylori activity of extracts of selected medicinal plants from North West Cameroon

摘要: Abstract Ethnopharmacological relevance: Helicobacter pylori, a gram negative microaerophilic bacterium is major etiological agent in duodenal, peptic and gastric ulcers. The growing problem of antibiotic resistance by the organism demands search for novel compounds from plant based sources. Aim Study present study aimed at evaluating antimicrobial activity some selected medicinal plants on clinical isolates H. pylori circulating Cameroon bid to identify potential sources cheap starting materials synthesis new drugs. Materials Methods Gastric biopsy samples were obtained patients presenting with gastroduodenal complications. was isolated specimens following standard microbiology procedures. disk diffusion method used determine susceptibility 15 ten methanol extracts (Ageratum conyzoides, Scleria striatinux, Lycopodium cernua, Acanthus montanus, Eryngium foetidium, Aulutandria kamerunensis, Tapeinachilus ananassae, Euphorbia hirta, Emilia coccinea verrucosa). minimum inhibitory concentration (MIC) bactericidal (MBC) most active also determined agar dilution method. Results analyzed statistically Fisher's exact test. All tested demonstrated zone diameters inhibition ranging 0–30 mm. Of these, A. S. striatinux L. cernua showed very potent antibacterial isolates. lowest MIC MBC recorded 0.032 mg/mL 0.098 mg/mL respectively. However, ranged 0.032–1.0 mg/mL striatinux; 0.063–0.5mg/mL 0.063–1.0 mg/mL conyzoides. 0.098–15.0 mg/mL 0.098–12.5 mg/mL 0.195–12.5 mg/mL cernua. had wide spectrum activity. three possessed significant (P  Conclusion may contain therapeutic