Bioinformatics and systems biology of cancers.

作者: Gilbert S. Omenn

DOI: 10.1016/B978-0-12-385071-3.00007-1

关键词:

摘要: Molecular databases and bioinformatics methods tools are essential for modern cancer research. Multilevel analyses of all the protein-coding genes, thousands proteins, hundreds metabolites require integration in terms signaling metabolic pathways networks. This chapter provides background examples genomic, gene expression, epigenomic, proteomic, metabolomic investigations progression emergence invasive metastatic properties cancers.

参考文章(66)
Eric W. Deutsch, The PeptideAtlas Project. Methods of Molecular Biology. ,vol. 604, pp. 285- 296 ,(2010) , 10.1007/978-1-60761-444-9_19
Imran N. Mungrue, Joanne Pagnon, Omid Kohannim, Peter S. Gargalovic, Aldons J. Lusis, CHAC1/MGC4504 Is a Novel Proapoptotic Component of the Unfolded Protein Response, Downstream of the ATF4-ATF3-CHOP Cascade Journal of Immunology. ,vol. 182, pp. 466- 476 ,(2009) , 10.4049/JIMMUNOL.182.1.466
Matthew B. Boxer, Jian-kang Jiang, Matthew G. Vander Heiden, Min Shen, Amanda P. Skoumbourdis, Noel Southall, Henrike Veith, William Leister, Christopher P. Austin, Hee Won Park, James Inglese, Lewis C. Cantley, Douglas S. Auld, Craig J. Thomas, Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. Journal of Medicinal Chemistry. ,vol. 53, pp. 1048- 1055 ,(2010) , 10.1021/JM901577G
C. Marks, Mouse Models of Human Cancers Consortium (MMHCC) from the NCI. Disease Models & Mechanisms. ,vol. 2, pp. 111- 111 ,(2009) , 10.1242/DMM.002725
Yoseph Barash, John A. Calarco, Weijun Gao, Qun Pan, Xinchen Wang, Ofer Shai, Benjamin J. Blencowe, Brendan J. Frey, Deciphering the splicing code Nature. ,vol. 465, pp. 53- 59 ,(2010) , 10.1038/NATURE09000
Laurent Bracco, Jonathan Kearsey, The relevance of alternative RNA splicing to pharmacogenomics Trends in Biotechnology. ,vol. 21, pp. 346- 353 ,(2003) , 10.1016/S0167-7799(03)00146-X
T Barrette, A Pandey, AM Chinnaiyan, ONCOMINE: A Cancer Microarray Database and Integrated Data-Mining Platform Neoplasia. ,vol. 6, pp. 1- 6 ,(2004) , 10.1016/S1476-5586(04)80047-2
Roded Sharan, Trey Ideker, Modeling cellular machinery through biological network comparison Nature Biotechnology. ,vol. 24, pp. 427- 433 ,(2006) , 10.1038/NBT1196
Diane M Simeone, Baoan Ji, Mousumi Banerjee, Thiruvengadam Arumugam, Dawei Li, Michelle A Anderson, Ann Marie Bamberger, Joel Greenson, Randal E Brand, ViJaya Ramachandran, Craig D Logsdon, None, CEACAM1, a novel serum biomarker for pancreatic cancer. Pancreas. ,vol. 34, pp. 436- 443 ,(2007) , 10.1097/MPA.0B013E3180333AE3
Heather R. Christofk, Matthew G. Vander Heiden, Ning Wu, John M. Asara, Lewis C. Cantley, Pyruvate kinase M2 is a phosphotyrosine-binding protein Nature. ,vol. 452, pp. 181- 186 ,(2008) , 10.1038/NATURE06667