Factors Contributing to the Antiviral Effectiveness of Tenofovir

摘要: Over 1 million people in the United States are living with human immunodeficiency virus (HIV), which may progress to AIDS. The use of antiviral therapy has successfully controlled rate viral growth patients. Antiviral agents improve quality life and reduce potential for spreading HIV; HIV is currently considered a chronic disease provided patients compliant their medications. Tenofovir nucleoside transcriptase inhibitor that prevents replication approved treatment hepatitis B infection. an antiretroviral drug used alone combination other reverse-transcriptase lower load administered as prodrug increase bioavailability. forms tenofovir disoproxil fumarate, 2001, alafenamide, 2016. extensively controlling HIV, it once daily, allowing good compliance. This minireview discusses impact food, age, transporters on absorption clearance. changes dosing needed presence renal impairment, common occurrence progression, will also be discussed. special conditions occurring fixed-combination doses containing reviewed, including cobicistat, cytochrome P450 3A4 inhibitor. short review addresses some newer preparations using niosomes delivery target cells.