Effects of Familial Mutations on the Monomer Structure of Aβ42
作者： Yu-Shan Lin , Vijay S. Pande
DOI: 10.1016/J.BPJ.2012.11.009
关键词:
摘要: Amyloid beta (Aβ) peptide plays an important role in Alzheimer’s disease. A number of mutations the Aβ sequence lead to familial disease, congophilic amyloid angiopathy, or hereditary cerebral hemorrhage with amyloid. Using molecular dynamics simulations ∼200 μs for each system, we characterize and contrast consequences four pathogenic (Italian, Dutch, Arctic, Iowa) structural ensemble monomer. The are found have distinct monomer structure.
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