Prefrontal contributions to relational encoding in amnestic mild cognitive impairment.

摘要: Relational memory declines are well documented as an early marker for amnestic mild cognitive impairment (aMCI). Episodic formation relies on relational processing supported by two mnemonic mechanisms, generation and binding. Neuroimaging studies using functional magnetic resonance imaging (fMRI) have primarily focused binding deficits which thought to be mediated medial temporal lobe dysfunction. In this study, prefrontal contributions encoding were also investigated fMRI parametrically manipulating demands during the of word triads. Participants diagnosed with aMCI healthy control subjects encoded triads consisting a category either, zero, one, or semantically related exemplars. As need generate increased (i.e., two- one- zero-link triads), both groups recruited core set regions associated including parahippocampal gyrus, superior parietal lobule. several frontal inferior gyrus middle increased, whereas participants did not show modulation. While there is some overlap in between groups, recruitment coincides worse performance, likely representing form neural inefficiency Alzheimer's disease.