Characterization of anti-factor VIII antibody in a patient with acquired hemophilia A.
作者： Jisu Oh , Yeongmin Lim , Moon Ju Jang , Ji Young Huh , Midori Shima
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摘要: Acquired hemophilia A (AHA) is a bleeding disorder caused by the development of an auto-antibody against endogenous factor VIII (FVIII). In this study, epitope autoantibody was identified in 67-year-old female patient with AHA. prolonged activated partial thromboplastin time (77.4 s) that failed to correct incubation mixing test (68.2 s), decreased FVIII activity, and high inhibitor (14.6 Bethesda units/mL) were observed. Enzyme-linked immunosorbent assay demonstrated antibody belonged immunoglobulin G4 subclass. An immunoblotting revealed light chain (A3/C1/C2 domain) as binding region antibody. The experienced our resulted from interference both FIX anti-A3 antibodies phospholipids von Willebrand anti-C2 antibodies. To best knowledge, first study Korea characterizing context
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