Targets and mechanisms of chemically induced aneuploidy. Part 1 of the report of the 2017 IWGT workgroup on assessing the risk of aneugens for carcinogenesis and hereditary diseases.

摘要: An aneuploidy workgroup was established as part of the 7th International Workshops on Genotoxicity Testing. The conducted a review scientific literature biological mechanisms in mammalian cells and methods used to detect chemical aneugens. In addition, current regulatory framework discussed, with objective arrive at consensus statements ramifications exposure aneugens for human health risk assessment. As these efforts, explored use adverse outcome pathways (AOPs) document chemically induced somatic cells. group worked two molecular initiating events (MIEs), tubulin binding catalytic domain aurora kinase B, which result several outcomes, including aneuploidy. agreed that AOP provides useful approach link evidence MIEs cellular level. linking carcinogenicity hereditary disease also reviewed is presented companion papers. came test batteries, while not ideal, are sufficient identification While it obvious there many different could lead induction aneuploidy, most commonly observed involving related and, lesser extent, inhibition mitotic kinases. comprehensive here should help management aneugenic agents.