作者: Xuejiao J. Gao , Xiaomei Shen , Gengmei Xing , Xingfa Gao
DOI: 10.1007/978-3-319-89878-0_12
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摘要: Chemical derivatives of fullerene and endohedral metallofullerenes (EMFs) not only keep some the physicochemical properties their parent molecules, but can also have water solubility biocompatibility that are owned by molecules. These brilliant provide these materials potentials in biomedical applications. Here, we review atomistic-level structural models for derivatives, applications as magnetic resonance imaging (MRI) contrast cancer therapy agents. Because atomistic level structures base properties, first which applicable to synthesized different conditions. Second, widely explored Gd-containing EMF safe efficient MRI agents, thanks special geometries electronic structures. Reportedly, fullerene-based materials, like Gd@C82(OH)22 nanoparticles, possess intrinsic antitumor activities. The recent advance using through pathways, including photodynamic (PDT), reactive oxygen species (ROS) scavenging, drug delivery, adjuvant activity vaccines, reduction nutrient supply tumor cells, further summarized. Finally, briefly discuss challenges perspectives future derivatives.