Fullerenes for Cancer Therapy and Bioimaging

作者: Xuejiao J. Gao , Xiaomei Shen , Gengmei Xing , Xingfa Gao

DOI: 10.1007/978-3-319-89878-0_12

关键词:

摘要: Chemical derivatives of fullerene and endohedral metallofullerenes (EMFs) not only keep some the physicochemical properties their parent molecules, but can also have water solubility biocompatibility that are owned by molecules. These brilliant provide these materials potentials in biomedical applications. Here, we review atomistic-level structural models for derivatives, applications as magnetic resonance imaging (MRI) contrast cancer therapy agents. Because atomistic level structures base properties, first which applicable to synthesized different conditions. Second, widely explored Gd-containing EMF safe efficient MRI agents, thanks special geometries electronic structures. Reportedly, fullerene-based materials, like Gd@C82(OH)22 nanoparticles, possess intrinsic antitumor activities. The recent advance using through pathways, including photodynamic (PDT), reactive oxygen species (ROS) scavenging, drug delivery, adjuvant activity vaccines, reduction nutrient supply tumor cells, further summarized. Finally, briefly discuss challenges perspectives future derivatives.

参考文章(157)
H. W. Kroto, J. R. Heath, S. C. O’Brien, R. F. Curl, R. E. Smalley, C 60 : Buckminsterfullerene Nature. ,vol. 318, pp. 162- 163 ,(1985) , 10.1038/318162A0
De Yang, Yuliang Zhao, Hua Guo, Yana Li, Poonam Tewary, Gengmei Xing, Wei Hou, Joost J. Oppenheim, Ning Zhang, [Gd@C(82)(OH)(22)](n) nanoparticles induce dendritic cell maturation and activate Th1 immune responses. ACS Nano. ,vol. 4, pp. 1178- 1186 ,(2010) , 10.1021/NN901478Z
Kursad Turksen, Isolation and characterization Humana Press. ,(2006)
Tinghui Li, Susan Murphy, Boris Kiselev, Kanwarpal S. Bakshi, Jianyuan Zhang, Amnah Eltahir, Yafen Zhang, Ying Chen, Jie Zhu, Richey M. Davis, Louis A. Madsen, John R. Morris, Daniel R. Karolyi, Stephen M. LaConte, Zhi Sheng, Harry C. Dorn, A New Interleukin-13 Amino-Coated Gadolinium Metallofullerene Nanoparticle for Targeted MRI Detection of Glioblastoma Tumor Cells. Journal of the American Chemical Society. ,vol. 137, pp. 7881- 7888 ,(2015) , 10.1021/JACS.5B03991
Yuanming Pan, Liming Wang, Seung-gu Kang, Youyong Lu, Zaixing Yang, Tien Huynh, Chunying Chen, Ruhong Zhou, Mingzhou Guo, Yuliang Zhao, Gd-Metallofullerenol Nanomaterial Suppresses Pancreatic Cancer Metastasis by Inhibiting the Interaction of Histone Deacetylase 1 and Metastasis-Associated Protein 1 ACS Nano. ,vol. 9, pp. 6826- 6836 ,(2015) , 10.1021/NN506782F
Henry Jay Forman, Martine Torres, Reactive oxygen species and cell signaling: respiratory burst in macrophage signaling. American Journal of Respiratory and Critical Care Medicine. ,vol. 166, ,(2002) , 10.1164/RCCM.2206007
Julie Lotharius, Laura L. Dugan, Karen L. O’Malley, Distinct Mechanisms Underlie Neurotoxin-Mediated Cell Death in Cultured Dopaminergic Neurons The Journal of Neuroscience. ,vol. 19, pp. 1284- 1293 ,(1999) , 10.1523/JNEUROSCI.19-04-01284.1999
Naoto Miwa, Hisanori Shinohara, Masahito Mikawa, Haruhito Kato, Masafumi Okumura, Michiko Narazaki, Yoko Kanazawa, Paramagnetic water-soluble metallofullerenes having the highest relaxivity for MRI contrast agents. Bioconjugate Chemistry. ,vol. 12, pp. 510- 514 ,(2001) , 10.1021/BC000136M
Jun-peng Zheng, Ming-Ming Zhen, Jie-Chao Ge, Qiao-Ling Liu, Feng Jiang, Chun-Ying Shu, Hisham A. Alhadlaq, Chun-Ru Wang, Multifunctional gadofulleride nanoprobe for magnetic resonance imaging/fluorescent dual modality molecular imaging and free radical scavenging Carbon. ,vol. 65, pp. 175- 180 ,(2013) , 10.1016/J.CARBON.2013.08.011