Prognostic significance of the worst grade in hepatocellular carcinoma with heterogeneous histologic grades of differentiation

摘要: Background and aim Although tumor differentiation is a known prognostic factor after the treatment of hepatocellular carcinoma (HCC), there have not been any studies on significance in HCC with heterogeneous histologic grades. In this study, we attempted to ascertain whether major or worst grade mixed type determines prognosis liver resection. Methods From January 1996 March 2010, total 724 patients underwent curative resection at Yonsei University Health System, Korea. Of those, excluded 99 who had necrosis because previous treatment. Among remaining 625 patients, compared homogeneous moderately differentiated group (HG2, n = 241), grades component as poorly (M2, 142), (HG3, 156). The clinicopathologic features, disease-free survival (DFS) overall (OS) each were analyzed. Results DFS OS significantly lower M2 than HG2 (P 0.004 0.025, respectively) whereas those different from HG3. There no significant differences features except that microvascular invasion was more frequently observed HG2. On multivariate analysis, being (M2 HG3) an independent poor for 0.028 Conclusions advanced grade, may determine HCC.