Sodium-Hydrogen Antiport, Cell Function and Susceptibility to Diabetic Nephropathy

摘要: The annual incidence of diabetic nephropathy rises rapidly over the first 15–20 years diabetes, but declines sharply afterward for longer disease duration [1]. This pattern risk indicates that only a subset patients are susceptible to renal damage and, indeed, clinical cumulatively develops in approximately 30% insulin-dependent (IDDM) [2] and between 15 60% non-insulin-dependent (NIDDM) patients, depending on their ethnic origin [3]. Familial clustering has been shown both IDDM [4] NIDDM [5]. These findings consistent with possibility genetic factors may explain liability or protection from patients.