1H-MRS of intracranial meningiomas: What it can add to known clinical and MRI predictors of the histopathological and biological characteristics of the tumor? ☆

摘要: Abstract Objective The main goal of the present study was evaluation proton magnetic resonance spectroscopy ( 1 H-MRS) in diagnosis histopathologically aggressive intracranial meningiomas. Methods Single-voxel H-MRS 100 meningiomas performed before their surgical resection. Investigated metabolites included mobile lipids, lactate, alanine, N-acetylaspartate (NAA), and choline-containing compounds (Cho). According to criteria World Health Organization (WHO) 82 were assigned histopathological grade I, 11 II, 7 III. MIB-1 index varied from 0% 27.3% (median, 1.6%). In 43 cases tight adhesion tumor pia mater or brain tissue macroscopically identified at surgery. consistency 49 characterized as soft, 26 hard, 25 mixed. Results No one metabolic parameter had statistically significant association with subtype, invasive growth, meningioma. Univariate statistical analysis revealed greater H-MRS-detected Cho content P =0.0444) lower normalized NAA/Cho ratio =0.0203) tumors 5% more. However, both parameters lost significance during multivariate model along other clinical radiological variables. It that non-benign histopathology meningioma (WHO II/III) is mainly predicted by irregular shape =0.0076) large size =0.0316), increased proliferative activity =0.0056), growth prominent peritumoral edema =0.0021). Conclusion While may be potentially used for identification high activity, it, seemingly, could not add substantial diagnostic information predictors malignancy these tumors.