Intraperitoneal co-administration of low dose urethane with xylazine and ketamine for extended duration of surgical anesthesia in rats

摘要: Procedures involving complex surgical techniques in rats, such as placement of abdominal aortic graft require extended duration anesthesia, which often can be achieved by repeated administrations xylazine-ketamine combination. However anesthetic administration, addition to being technically challenging, may associated with potential adverse events due cumulative effects anesthesia. We report here the feasibility using urethane at low dose (~1/10 recommended dose) combination a mix achieve an anesthesia rats. The induction phase was quick and smooth optimal for up 90 minutes, significantly higher compared that use only rectal temperature, heart rate respiratory were within physiological range uneventful recovery phase. Post surgery rats followed 3 months without any evidence tumor or other related conclude effectively used xylazine ketamine minutes