Relationship between serum levels of macrophage migration inhibitory factor and the activity of antineutrophil cytoplasmic antibody-associated vasculitides
作者： Heidemarie Becker , Christian Maaser , Eva Mickholz , Anke Dyong , Wolfram Domschke
DOI: 10.1007/S10067-005-0045-9
关键词:
摘要: Macrophage migration inhibitory factor (MIF) is a central proinflammatory cytokine that regulates innate and adaptive immune responses. To evaluate its role in primary vasculitides, we determined MIF by enzyme-linked immunoassay the sera of patients with Wegener's granulomatosis (WG; n=26), microscopic polyangiitis (MPA; n=10), polyarteritis nodosa (PAN; n=9) giant cell arteritis (GCA; n=11). Healthy controls (n=26) sarcoidosis (n=14) were studied parallel. Serum levels significantly higher WG (median 41.1, range 3.2–120 ng/ml) than those healthy (6.0, 0.015–36.5 ng/ml; P<0.001) (13.8, 0.015–67.1 ng/ml; P<0.05). values MPA (29.5, 9.9–69.4 ng/ml; P<0.01) comparison controls. In particular, increased associated active disease as assessed Birmingham Vasculitis Activity Score. Sequential studies showed decreased after initiation immunosuppressive therapy, clinical improvement patients. contrast, serum not elevated PAN GCA. The results suggest contributes to inflammatory process correlates activity antineutrophil cytoplasmic antibody-associated vasculitides.
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