Effects of naloxone and of intraperitoneal hypertonic saline upon oxytocin release and upon supraoptic neuronal activity
作者： K. Shibuki , G. Leng , S. Way
DOI: 10.1016/0304-3940(88)90318-7
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摘要: Urethane anaesthetized male rats were given an i.p. injection of hypertonic saline to increase plasma osmotic pressure. This resulted in significantly elevated oxytocin levels and increased discharge activity putative cells the supraoptic nucleus. Subsequent naloxone (1 mg/kg) i.v. a similarly large oxytocin, but did not affect neurones. The results suggest that, following saline, endogenous opioids act at neurosecretory terminals partially inhibit release.
sci-hub.se 参考文章(24)
G. Clarke, Pat Wood, Lynda Merrick, D. W. Lincoln, Opiate inhibition of peptide release from the neurohumoral terminals of hypothalamic neurones Nature. ,vol. 282, pp. 746- 748 ,(1979) , 10.1038/282746A0
Henning Anhut, Willhart Knepel, Release of dynorphin-like immunoreactivity of rat neurohypophysis in comparison to vasopressin after various stimuli in vitro and in vivo Neuroscience Letters. ,vol. 31, pp. 159- 164 ,(1982) , 10.1016/0304-3940(82)90109-4
R. John Bicknell, Christopher Chapman, Gareth Leng, Effects of Opioid Agonists and Antagonists on Oxytocin and Vasopressin Release in vitro Neuroendocrinology. ,vol. 41, pp. 142- 148 ,(1985) , 10.1159/000124168
Joan Y. Summy-Long, Cheryl Denlinger, Donald Palm, Richard D. Hartman, Lillian M. Rosella-Dampman, Naloxone effects on plasma vasopressin and oxytocin concentrations elevated by histamine, nicotine, isoproterenol and an acute increase in [NaCl] in cerebrospinal fluid. Neuroendocrinology. ,vol. 44, pp. 157- 162 ,(1986) , 10.1159/000124639
James C. W. Finley, Jerome L. Maderdrut, Peter Petrusz, The immunocytochemical localization of enkephalin in the central nervous system of the rat The Journal of Comparative Neurology. ,vol. 198, pp. 541- 565 ,(1981) , 10.1002/CNE.901980402
P.E. Sawchenko, L.W. Swanson, S.A. Joseph, The distribution and cells of origin of ACTH(1–39)-stained varicosities in the paraventricular and supraoptic nuclei Brain Research. ,vol. 232, pp. 363- 374 ,(1982) , 10.1016/0006-8993(82)90280-3
R J Bicknell, G Leng, D W Lincoln, J A Russell, Naloxone excites oxytocin neurones in the supraoptic nucleus of lactating rats after chronic morphine treatment. The Journal of Physiology. ,vol. 396, pp. 297- 317 ,(1988) , 10.1113/JPHYSIOL.1988.SP016963
Rüdiger Gerstberger, Nicholas Barden, Dynorphin 1-8 binds to opiate kappa receptors in the neurohypophysis. Neuroendocrinology. ,vol. 42, pp. 376- 382 ,(1986) , 10.1159/000124475
C Chavkin, I. James, A Goldstein, Dynorphin is a specific endogenous ligand of the kappa opioid receptor. Science. ,vol. 215, pp. 413- 415 ,(1982) , 10.1126/SCIENCE.6120570
S. Watson, H Akil, W Fischli, A Goldstein, E Zimmerman, G Nilaver, T. van wimersma Griedanus, Dynorphin and vasopressin: common localization in magnocellular neurons. Science. ,vol. 216, pp. 85- 87 ,(1982) , 10.1126/SCIENCE.6121376