Tricyclo[4.2.2.02,5]dec-9-ene-3,4,7,8-tetracarboxlic Acid Diimide: Formulation and Stability Studies
作者： B. Rao Vishnuvajjala , James C. Cradock
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摘要: The experimental antitumor drug, tricyclo[4.2.2.02,5]dec-9-ene-3,4,7,8-tetracarboxlic acid diimide, NSC 284356, was formulated as the disodium salt in a stable freeze-dried form suitable for parenteral administration. stability of drug determined buffers at various temperatures using liquid chromatography. found to undergo hydrolysis aqueous solutions. rate hydrolysi hydrolysisfollowed pseudo-first-order kinetics and is accelerated by increases temperature pH product isolated its structure unambiguous chemical methods.
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sci-hub.se 参考文章(6)
Christopher M. Cimarusti, Joseph. Wolinsky, Synthesis and bisdecarboxylation of oxygenated bicyclo[2.2.X]alkanedicarboxylic anhydrides Journal of the American Chemical Society. ,vol. 90, pp. 113- 120 ,(1968) , 10.1021/JA01003A020
D. Bryce-Smith, J. E. Lodge, 514. Liquid-phase photolysis. Part V. Mechanism of the photo-addition of maleic anhydride to benzene Journal of the Chemical Society (Resumed). pp. 2675- 2680 ,(1962) , 10.1039/JR9620002675
C. A. Grob, M. Ohta, Andreas Weiss, Oxydative Bisdecarboxylierung von 1.2-Dicarbonsäuren mit Bleitetraacetat Angewandte Chemie. ,vol. 70, pp. 343- 344 ,(1958) , 10.1002/ANGE.19580701107
George R. Pettit, Kenneth D. Paull, Cherry L. Herald, Delbert L. Herald, Joseph R. Riden, The structure of the benzene―maleimide photosynthetic product (mitindomide) Canadian Journal of Chemistry. ,vol. 61, pp. 2291- 2294 ,(1983) , 10.1139/V83-397
Jerald S. Bradshaw, The photosensitized addition of maleimide to benzene in the absence of a charge-transfer complex Tetrahedron Letters. ,vol. 7, pp. 2039- 2042 ,(1966) , 10.1016/S0040-4039(00)76292-7
Walter Reppe, Otto Schlichting, Karl Klager, Tim Toepel, Cyclisierende Polymerisation von Acetylen I Über Cyclooctatetraen European Journal of Organic Chemistry. ,vol. 560, pp. 1- 92 ,(1948) , 10.1002/JLAC.19485600102