Increased Expression of Toll-Like Receptor 2 on Monocytes in HIV Infection: Possible Roles in Inflammation and Viral Replication
作者： L. Heggelund , F. Muller , E. Lien , A. Yndestad , T. Ueland
DOI: 10.1086/421780
关键词:
摘要: BACKGROUND Toll-like receptors (TLRs) are key pattern-recognition of the innate immune system, but their role in human immunodeficiency virus (HIV) infection is largely unknown. METHODS In present study, we examined expression TLR2 and TLR4 on monocytes from 48 HIV-infected patients 21 healthy control subjects by flow cytometry. RESULTS We found that freshly isolated displayed enhanced not TLR4, surface was significantly increased upon stimulation HIV type 1 envelope protein gp120, induced viral replication TNF- alpha response. CONCLUSION Our findings suggest potential roles for chronic activation infection.
oup.com
paperity.org
oxfordjournals.org参考文章(32)
G. M. Barton, R. Medzhitov, Toll-Like Receptors and Their Ligands Current Topics in Microbiology and Immunology. ,vol. 270, pp. 81- 92 ,(2002) , 10.1007/978-3-642-59430-4_5
Hernan Valdez, Immune restoration after treatment of HIV-1 infection with highly active antiretroviral therapy (HAART). Aids Reviews. ,vol. 4, pp. 157- ,(2002)
Keiko Ozato, Hideki Tsujimura, Tomohiko Tamura, Toll-like receptor signaling and regulation of cytokine gene expression in the immune system. BioTechniques. ,vol. 33, pp. 66- ,(2002) , 10.2144/OCT0208
Trude H. Flo, Øyvind Halaas, Egil Lien, Liv Ryan, Giuseppe Teti, Douglas T. Golenbock, Anders Sundan, Terje Espevik, Human Toll-Like Receptor 2 Mediates Monocyte Activation byListeria monocytogenes, But Not by Group B Streptococci or Lipopolysaccharide The Journal of Immunology. ,vol. 164, pp. 2064- 2069 ,(2000) , 10.4049/JIMMUNOL.164.4.2064
Angus G. Dalgleish, Ken J. O'Byrne, Chronic immune activation and inflammation in the pathogenesis of aids and cancer Advances in Cancer Research. ,vol. 84, pp. 231- 276 ,(2002) , 10.1016/S0065-230X(02)84008-8
Secondo Sonza, Suzanne M. Crowe, HIV-1 can be recovered from a variety of cells including peripheral blood monocytes of patients receiving highly active antiretroviral therapy: a further obstacle to eradication. Journal of Leukocyte Biology. ,vol. 68, pp. 345- 350 ,(2000) , 10.1189/JLB.68.3.345
Eric Ledru, Névéna Christeff, Olivier Patey, Pierre de Truchis, Jean-Claude Melchior, Marie-Lise Gougeon, None, Alteration of tumor necrosis factor–α T-cell homeostasis following potent antiretroviral therapy: contribution to the development of human immunodeficiency virus–associated lipodystrophy syndrome Blood. ,vol. 95, pp. 3191- 3198 ,(2000) , 10.1182/BLOOD.V95.10.3191
Ozlem Equils, Emmanuelle Faure, Lisa Thomas, Yonca Bulut, Sergey Trushin, Moshe Arditi, Bacterial Lipopolysaccharide Activates HIV Long Terminal Repeat Through Toll-Like Receptor 4 Journal of Immunology. ,vol. 166, pp. 2342- 2347 ,(2001) , 10.4049/JIMMUNOL.166.4.2342
Marta Muzio, Daniela Bosisio, Nadia Polentarutti, Giovanna D’amico, Antonella Stoppacciaro, Roberta Mancinelli, Cornelis van’t Veer, Giselle Penton-Rol, Luigi P. Ruco, Paola Allavena, Alberto Mantovani, Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells. Journal of Immunology. ,vol. 164, pp. 5998- 6004 ,(2000) , 10.4049/JIMMUNOL.164.11.5998
Tsuneyasu Kaisho, Shizuo Akira, Critical roles of Toll-like receptors in host defense. Critical Reviews in Immunology. ,vol. 20, pp. 393- 405 ,(2000) , 10.1615/CRITREVIMMUNOL.V20.I5.30