Frequent expression of the breast differentiation antigen NY-BR-1 in mammary and extramammary Paget's disease
作者： Olivier Giger , Rosmarie Caduff , Alix O'Meara , Pierre-Andre Diener , Alexander Knuth
DOI: 10.1111/J.1440-1827.2010.02591.X
关键词:
摘要: While mammary Paget's disease (MPD) is clearly linked to breast cancer, the histogenesis of extramammary (EMPD) controversial. Recently NY-BR-1, a differentiation antigen expressed in and skin adnexal structures was identified. Its protein expression restricted normal neoplastic epithelium tumors skin. In this study, we examine NY-BR-1 by immunohistochemistry 24 MPD cases with synchronous ductal carcinoma situ or invasive cancer. Results were compared 26 EMPD men (n= 4) women 22) as well apoeccrine glands axilla mammary-like anogenital region. We found positivity 18 (75%) 21 (80.8%). All region NY-BR-1-positive. common finding EMPD. When considering diagnosis disease, useful diagnostic marker. Furthermore suggests potential histogenetic link between these disease.
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