The effects of model androgen 5α-dihydrotestosterone on mummichog (Fundulus heteroclitus) reproduction under different salinities.

摘要: Endocrine disrupting substances (EDSs) have the potential to disturb sensitive hormone pathways, particularly those involved in development and reproduction. Both fresh estuarine water bodies receive inputs of EDSs from a variety sources, including sewage effluent, industrial effluent agricultural runoff. Based on current literature, freshwater species appear respond lower levels than or marine species. Therefore, effects elicited by teleosts may not be an accurate representation how affect environments. To address this difference, short-term reproductive bioassay was conducted under conditions low high salinity using mummichog (Fundulus heteroclitus), euryhaline that is native east coast North America. The goals study were determine response when exposed androgenic EDS whether affected response. A model androgen, 5α-dihydrotestosterone (DHT), selected for experiment. Impacts reproduction evaluated at multiple biological levels, physiological (sex steroid levels), organismal (gonad size gonad morphology), functional (egg production) endpoints. Under salinity, egg production significantly reduced all exposure concentrations. there no significant differences based DHT treatment; however, treatment groups control relative group. Other endpoints, such as sex production, showed stronger correlation fecundity females males. This demonstrates endocrine disruption while also underscoring importance changes environmental variable, can impact