Efficacy of Multimodal Perioperative Analgesia Protocol With Periarticular Medication Injection in Total Knee Arthroplasty: A Randomized, Double-Blinded Study

作者: Todd C. Kelley , Mary Jo Adams , Brian D. Mulliken , David F. Dalury

DOI: 10.1016/J.ARTH.2013.03.008

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摘要: article i nfo Pain control is necessary for successful rehabilitation and outcome after total knee arthroplasty. Our goal was to compare the clinical efficacy of periarticular injections consisting a long-acting local anesthetic (ropivacaine) epinephrine with without combinations an α2-adrenergic agonist (clonidine) and/ or nonsteroidal anti-inflammatory agent (ketorolac). In double-blinded controlled study, we randomized 160 patients undergoing arthroplasty receive 1 4 intraoperative injections: Group A, ropivacaine, epinephrine, ketorolac, clonidine; B, ketorolac; C, D (control), ropivacaine epinephrine. Compared D, A B had significantly lower postoperative visual analog pain scores nurse assessment C greater reduction in physical therapist assessment. We found no differences other parameters analyzed.

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