Effects Of Triptolide On Tooth Movement And Root Resorption In Rats.
作者： Fan Yang , Xu Xia Wang , Dan Ma , Qun Cui , De Hua Zheng
DOI: 10.2147/DDDT.S217936
关键词:
摘要: Purpose The aim of this study was to investigate the effects triptolide on tooth movement and root resorption in rats during orthodontic treatment. Material methods A total 48 male Wistar were divided into three groups 16 each. right maxillary first molars drawn mesially by closed coil nickel-titanium spring with a force 50 g. two experimental received intraperitoneal injections for 14 days at dose 15 µg/kg/day 30 µg/kg/day, respectively. control group vehicle injections. After days, humanely killed. amount measured. Eight from each randomly chosen analysis percentage area scanning electron microscopy. For remaining eight group, H&E staining, tartrate-resistant acid phosphatase (TRAP) staining immunohistochemistry performed. Results ratio significantly decreased triptolide-treated rats. number TRAP-positive cells lower groups. Moreover, expression nuclear factor kappa B ligand (RANKL) reduced. In contrast, osteoprotegerin up-regulated. tension side, expressions runt-related transcription 2 osteocalcin enhanced injection. Conclusion Triptolide injection could arrest reduce via inhibition osteoclastogenesis. addition, may exert positive effect osteoblastogenesis.
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