Effect of sodium ozagrel on platelet rich plasma clot lysis
作者： H Yuasa , K Okada , S Ueshima , O Matsuo
DOI: 10.1016/S0928-4680(97)00013-8
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摘要: Abstract Sodium ozagrel inhibits platelet aggregation through thromboxane (TX) synthetase inhibition. In vitro, the combination of antiplatelet agents with plasminogen activators (PAs) is more effective for thrombolytic therapy than are PAs alone. Therefore, influence sodium on rich plasma (PRP) clot lysis was investigated in this study. Firstly, PRP performed: clots containing were lyzed by a urokinase-type PA. significantly enhanced dose-dependent manner. Secondly, solubility urea test. The Moreover, density studied. decreased PAI-1 antigen which released from activated platelets reduced These findings indicate that enhancement due to solubility, and release.
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