Antithetic relationship of dietary arachidonic acid and eicosapentaenoic acid on eicosanoid production in vivo.

摘要: Eicosanoids are oxidative derivatives of arachidonic acid. When produced in excessive amounts, many proinflammatory and/or prothrombotic agents. N-3 polyunsaturated fatty acids (PUFA) have been used to attenuate tissue acid (AA, 20:4 n-6) levels and thus modulate eicosanoid production. However, there is growing evidence that dietary may also be able formation by enriching phospholipids with AA. Therefore, the effects AA n-3 PUFA diametric opposition. This study investigates antithetic relationship eicosapentaenoic (EPA, 20:5 n-3) on composition hepatic production vivo. Forty-nine CD-1 male mice were randomly divided into four groups. Identical diets supplemented ethyl esters (1.5% w/w) following acids: oleic (OA, 18:1 n-9), AA, EPA or AA+EPA. After 4 weeks diet, peritoneal cells stimulated vivo opsonized zymosan exudates analyzed for (PGE2, 6-keto-PGF1 alpha, TXB2, LTB4, LTE4, LTE5). Hepatic enriched when was included at expense added diet. diet containing equivalent amounts (AA+EPA), any effect had modulating phospholipid almost completely eliminated. Similar observed The pooled group 41% 300% higher compared OA (control) groups, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)