Review Article; Duodeno-Gastro-Esophageal Reflux Combined and Isolated

摘要: Barrett’s esophagus is the chief risk factor for esophageal adenocarcinoma. Reflux of gastric acid has long been related to development esophagitis and esophagus, but role duodenal contents controversial. We review literature on in esophagitis, adenocarcinoma addition suppressant therapy or prevention these changes. A computer-based search using terms "Bilirubin, Barrett, Bile Reflux, duodeno-gastric reflux oesophagus/esophagus" was performed. The bile other constituents refluxate were examined. Techniques identifying non-acid also reviewed, as pH, medication surgery modulating disease severity. Complicated associated with increased exposure refluxate. Biological effect acids depends conjugation status, pH milieu pKa acids. While Proton Pump Inhibitors reduce levels DGER, they produce changes lower that activate different at resulting unexpected injury. Conjugated are harmful acidic environment while unconjugated neutral environment. An overlap toxicity among conjugated occurs between strongly levels. Normalisation should ideally be goal treatment.