The effect of Hibiscus sabdariffa calyx extract on cisplatin-induced tissue damage in rats

摘要: The effect of Hibiscus sabdariffa calyx extract on cisplatin-induced tissue damage was studied. A total twenty rats were used for the study and split into four groups five per group-group I, II, III, IV. Tissue induced in IV by a single intraperitoneal administration cisplatin (5 mg/kg b.w.). Four days later, III given 200 b.w. 300 b.w respectively once daily another days. Rats group I untreated controls. later assessed sera measuring levels alanine aminotransferase, aspartate urea, creatinine. Thiobarbituric acid reactive species, catalase, reduced glutathione also measured livers kidneys. results reveal that alone resulted to significant increase serum markers over controls (p liver kidney with dose possessing higher activity. show ameliorated which may be dose-dependent.