Cinical and pathological characteristics of Chinese patients with antineutrophil cytoplasmic autoantibody associated systemic vasculitides: a study of 426 patients from a single centre
作者： M Chen , F Yu , Y Zhang , MH Zhao
关键词:
摘要: Background: Antineutrophil cytoplasmic autoantibodies (ANCA) are serological markers of ANCA associated systemic vasculitides (AASV), which is one the most common multisystem autoimmune diseases. Features Chinese patients with AASV have not been fully investigated. Objective: To analyse clinical and pathological characteristics AASV. Methods: 426 diagnosed in past eight years were retrospectively studied their data analysed. Results: Of patients, 87 (20.4%) Wegener's granulomatosis, 337 (79.1%) microscopic polyangiitis two (0.5%) Churg-Strauss syndrome. Only 201 (47.2%) within three months. Clinically, had involvement. Altogether 371 (87.1%) kidney involvement 260 (61.0%) lung The prevalences renal fatigue significantly higher MPO-ANCA than that PR3-ANCA; ophthalmic, nasal involvement, rash, arthragia PR3-ANCA those MPO-ANCA. five year death rates 13.1% 22.4%, respectively. percentage progressing to end stage disease at was 15.9% 27.1%, Conclusions: a rare people. Kidney vulnerable organs. For multiorgan damage, an test should be performed make early diagnosis start treatment time.
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