Plasminogen/Plasmin Modulates Bone Metabolism by Regulating the Osteoblast and Osteoclast Function
作者： Yosuke Kanno , Akira Ishisaki , Eri Kawashita , Naoyuki Chosa , Keiichi Nakajima
关键词:
摘要: The contribution of plasminogen (Plg)/plasmin, which have claimed to be the main fibrinolytic regulators in bone metabolism, remains unclear. This study evaluated how absence Plg affects function osteoblast (OB) and osteoclast (OC). There was a larger population pre-OCs marrow-derived cells from Plg−/− mice than that WT mice. In addition, suppressed expression osteoprotegerin OBs. Moreover, an exogenous plasmin clearly induced osteoclastogenesis RAW264.7 mouse monocyte/macrophage lineage co-culture with OBs significantly accelerated comparison Intriguingly, OC differentiation co-cultured by treatment plasmin. Consequently, display decreased mineral density. These findings could eventually lead development new clinical therapies for disease caused disorder system.
highwire.org参考文章(27)
JV Braaten, S Handt, WG Jerome, J Kirkpatrick, JC Lewis, RR Hantgan, Regulation of fibrinolysis by platelet-released plasminogen activator inhibitor 1: light scattering and ultrastructural examination of lysis of a model platelet-fibrin thrombus. Blood. ,vol. 81, pp. 1290- 1299 ,(1993) , 10.1182/BLOOD.V81.5.1290.1290
J. Li, I. Sarosi, X.-Q. Yan, S. Morony, C. Capparelli, H.-L. Tan, S. McCabe, R. Elliott, S. Scully, G. Van, S. Kaufman, S.-C. Juan, Y. Sun, J. Tarpley, L. Martin, K. Christensen, J. McCabe, P. Kostenuik, H. Hsu, F. Fletcher, C. R. Dunstan, D. L. Lacey, W. J. Boyle, RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism Proceedings of the National Academy of Sciences of the United States of America. ,vol. 97, pp. 1566- 1571 ,(2000) , 10.1073/PNAS.97.4.1566
E Daci, V Everts, S Torrekens, E Van Herck, W Tigchelaar-Gutterr, R Bouillon, G Carmeliet, Increased bone formation in mice lacking plasminogen activators. Journal of Bone and Mineral Research. ,vol. 18, pp. 1167- 1176 ,(2003) , 10.1359/JBMR.2003.18.7.1167
E. Daci, A. Verstuyf, K. Moermans, R. Bouillon, G. Carmeliet, Mice Lacking the Plasminogen Activator Inhibitor 1 Are Protected from Trabecular Bone Loss Induced by Estrogen Deficiency Journal of Bone and Mineral Research. ,vol. 15, pp. 1510- 1516 ,(2000) , 10.1359/JBMR.2000.15.8.1510
E. Daci, N. Udagawa, T. J. Martin, R. Bouillon, G. Carmeliet, The Role of the Plasminogen System in Bone Resorption In Vitro Journal of Bone and Mineral Research. ,vol. 14, pp. 946- 952 ,(1999) , 10.1359/JBMR.1999.14.6.946
Teiji Wada, Tomoki Nakashima, Nishina Hiroshi, Josef M Penninger, RANKL–RANK signaling in osteoclastogenesis and bone disease Trends in Molecular Medicine. ,vol. 12, pp. 17- 25 ,(2006) , 10.1016/J.MOLMED.2005.11.007
Mousumi Majumdar, Takehiko Tarui, Biao Shi, Nobuaki Akakura, Wolfram Ruf, Yoshikazu Takada, Plasmin-induced migration requires signaling through protease-activated receptor 1 and integrin α9β1 Journal of Biological Chemistry. ,vol. 279, pp. 37528- 37534 ,(2004) , 10.1074/JBC.M401372200
Hiroyuki Matsuno, Akira Ishisaki, Keiichi Nakajima, Kiyotaka Okada, Shigeru Ueshima, Osamu Matsuo, Osamu Kozawa, Lack of α2-antiplasmin promotes re-endothelialization via over-release of VEGF after vascular injury in mice Blood. ,vol. 102, pp. 3621- 3628 ,(2003) , 10.1182/BLOOD-2003-03-0700
Victoria A. Ploplis, Peter Carmeliet, Shahrzad Vazirzadeh, Ilse Van Vlaenderen, Lieve Moons, Edward F. Plow, Désiré Collen, Effects of Disruption of The Plasminogen Gene on Thrombosis, Growth, and Health in Mice Circulation. ,vol. 92, pp. 2585- 2593 ,(1995) , 10.1161/01.CIR.92.9.2585
Yosuke Kanno, Eri Kawashita, Misato Minamida, Aki Kaneiwa, Kiyotaka Okada, Shigeru Ueshima, Osamu Matsuo, Hiroyuki Matsuno, α2-Antiplasmin Is Associated with the Progression of Fibrosis American Journal of Pathology. ,vol. 176, pp. 238- 245 ,(2010) , 10.2353/AJPATH.2010.090150