Compositions and methods for modulating cells via cd14 and toll-like receptor 4 signaling pathway
作者： Zhengfan Jiang , Bruce Beutler
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摘要: Compositions and methods are provided for screening identifying compounds which modulate signaling of toll-like receptor 4 (TLR4) pathway via CD 14 a ligand. Methods treatment various disease states such as inflammation or autoimmune in mammalian subjects by modulating Transgenic non-human animals developing transgenic wherein the comprise loss-of-function mutation gene.
lens.org 参考文章(4)
Evelyn A. Kurt-Jones, Lana Popova, Laura Kwinn, Lia M. Haynes, Les P. Jones, Ralph A. Tripp, Edward E. Walsh, Mason W. Freeman, Douglas T. Golenbock, Larry J. Anderson, Robert W. Finberg, Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus Nature Immunology. ,vol. 1, pp. 398- 401 ,(2000) , 10.1038/80833
Zhengfan Jiang, Philippe Georgel, Xin Du, Louis Shamel, Sosathya Sovath, Suzanne Mudd, Michael Huber, Christoph Kalis, Simone Keck, Chris Galanos, Marina Freudenberg, Bruce Beutler, CD14 is required for MyD88-independent LPS signaling Nature Immunology. ,vol. 6, pp. 565- 570 ,(2005) , 10.1038/NI1207
Ting-fan Leung, Nelson Tang, Gary Wong, Tai-fai Fok, CD14 and toll-like receptors: potential contribution of genetic factors and mechanisms to inflammation and allergy. Current Drug Targets - Inflammation & Allergy. ,vol. 4, pp. 169- 175 ,(2005) , 10.2174/1568010053586336
Martin S Weber, Michaela Starck, Stefan Wagenpfeil, Edgar Meinl, Reinhard Hohlfeld, Cinthia Farina, None, Multiple sclerosis: glatiramer acetate inhibits monocyte reactivity in vitro and in vivo Brain. ,vol. 127, pp. 1370- 1378 ,(2004) , 10.1093/BRAIN/AWH163