Height in relation to dementia death: individual participant meta-analysis of 18 UK prospective cohort studies

摘要: Background That risk factors measured in middle age may not fully explain future dementia implicates exposures acting earlier life. Height capture early-life illness, adversity, nutrition and psychosocial stress. Aims To investigate the little-explored association between height death. Method Individual participant meta-analysis using 18 prospective general population cohort studies with identical methodologies (1994-2008; n = 181 800). Results Mean follow-up of 9.8 years gave rise to 426 667 deaths men women respectively. The mean heights were 174.4 cm (s.d. 7.3) for 161.0 6.8) women. In analyses taking into account multiple covariates, increasing was related lower rates death from a dose-response pattern ( P ⩽0.01 trend). There evidence differential effect by gender 0.016 interaction). Thus, observed (hazard ratio per s.d. decrease 1.24, 95% CI 1.11-1.39) markedly stronger than that apparent (HR 1.13, 1.03-1.24). Conclusions Early-life circumstances, indexed adult height, influence later risk.