Endotoxemia unrequired in the pathogenesis of pediatric nonalcoholic steatohepatitis.
作者： Jianye Yuan , Susan S Baker , Wensheng Liu , Razan Alkhouri , Robert D Baker
DOI: 10.1111/JGH.12510
关键词:
摘要: Background and Aim Nonalcoholic steatohepatitis (NASH), the severe form of nonalcoholic fatty liver disease, is a serious complication associated with obesity. Several studies suggest that endotoxemia disease NASH. We aimed to study correlation gut microbiome composition incidence in obese patients NASH comparison normal controls. Methods The abundance Gram-negative bacteria microbiomes controls, liver, biopsy-proven were assessed using 16S rRNA pyrosequencing data. Serum endotoxin was determined by endpoint limulus amebocyte lysate assay. Results Higher observed but no difference detected between patients. higher group than controls. In addition, had compared However, Spearman's test found serum levels. The majority low level. Among patients, not correlated severity. Conclusions Our data does contribute NASH, required pathogenesis Our observations highlight current concept multiple factors development
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