Quantitative phenomenological model of the BOLD contrast mechanism.

摘要: Different theoretical models of the BOLD contrast mechanism are used for many applications including quantification (qBOLD) and vessel size imaging, both in health disease. Each model simplifies system under consideration, making approximations about structure blood network diffusion water molecules through inhomogeneities magnetic field created by deoxyhemoglobin-containing vessels. In this study, Monte-Carlo methods to simulate MR signal generated diffusing presence long, cylindrical Using these simulations we introduce a new, phenomenological that is far more accurate over range oxygenation levels radii than existing models. This could be extract physiological parameters from experimental data BOLD-based experiments. We use our establish ranges validity analytical Yablonskiy Haacke, Kiselev Posse, Sukstanskii (extended case arbitrary time spin echo sequence) Bauer et al. randomly oriented cylinders). Although shown limits which they were derived, none them whole vessels levels. also show extent systematic errors introduced due when quantification.