A phase II study of preoperative oxaliplatin, capecitabine, and external beam radiotherapy in patients with locally advanced rectal adenocarcinoma. : Abstract #3552

摘要: 3552 Background: Local recurrence after surgery is a cause of treatment failure in pts with locally advanced rectal cancer (LARC). Preoperative RT decreases local but not distant spread. Oxaliplatin (OX) and capecitabine (CAP) are both highly active drugs for colorectal have radiosensitizing properties. Therefore, adding CAP OX to preoperative should improve its efficacy terms control prevention metastases. Methods: This study was designed investigate the (based on pathological response rate) safety chemo-RT patients LACR (T3-T4 and/or N+ staged by endorectal ultrasound). administered 5 weeks, days week (1.8 Gy/fraction, total dose 45 Gy, 3D conformation technique) combination 50 mg/m2 intravenously, weekly weeks oral 825 twice day, each day radiation. Surgery performed 6–8 completion RT. Results: Since December 2002, 37 out 40...