Signaling revealed by mapping molecular interactions

摘要: Abstract The ErbB2 (HER2) protein is a member of the EGF receptor (ErbB) family transmembrane tyrosine kinases. Although no direct ligand has yet been assigned to ErbB2, recent biochemical and biophysical evidence suggests that this operates as shared subunit with other ErbB proteins. Its medical importance stems form its frequent overexpression in breast cancers, resulting various tumorigenic phenotypic changes, including higher transforming activity, metastatic potential, angiogenesis drug resistance. multitude possible small-scale large-scale interactions among proteins makes them especially diverse important initiating directing signal transduction. mechanisms homo- hetero-associations cell membrane relation transduction events remain critical focus investigation. Recent studies map molecular involved signaling network are elucidating these mechanisms, promise facilitate development new ErbB-targeted therapies, approaches using antibodies, immunoliposomes, cancer vaccines, gene therapy small molecule inhibitors.