摘要: Our understanding of the pathogenesis type 1 diabetes mellitus has traditionally revolved around insulin deficiency that follows pancreatic beta cell loss. However, there is an increasing appreciation defects in other gluco-regulatory cells mellitus. Oversecretion glucagon from alpha characteristic mellitus, and modulating these levels reduces hyperglycaemia. This article reviews function We examine how its controlled compromised, review studies target function. Finally, we explore potential approaches to
bjd-abcd.com
bjdvd.co.uk参考文章(64)
Eva Tsalikian, John H. Karam, Mara Lorenzi, Nancy Bohannon, Duration of type I diabetes affects glucagon and glucose responses to insulin-induced hypoglycemia. Western Journal of Medicine. ,vol. 141, pp. 467- 471 ,(1984)
Jillian L Dunphy, Russel G Taylor, Peter J Fuller, Tissue distribution of rat glucagon receptor and GLP-1 receptor gene expression. Molecular and Cellular Endocrinology. ,vol. 141, pp. 179- 186 ,(1998) , 10.1016/S0303-7207(98)00096-3
PETER R. FLATT, SARA K. SWANSTON-FLATT, CLIFFORD J. BAILEY, Glucagon antiserum: a tool to investigate the role of circulating glucagon in obese-hyperglycaemic (ob/ob) mice [proceedings]. Biochemical Society Transactions. ,vol. 7, pp. 911- 913 ,(1979) , 10.1042/BST0070911
J. Foley, M. Ligueros-Saylan, Y.-L. He, J. Holst, C. Deacon, B. Dunning, A. Leone-Jones, T. Yu, D. Kelley, Effect of vildagliptin on glucagon concentration during meals in patients with type 1 diabetes. Hormone and Metabolic Research. ,vol. 40, pp. 727- 730 ,(2008) , 10.1055/S-2008-1078754
C. Levetan, L. L. Want, C. Weyer, S. A. Strobel, J. Crean, Y. Wang, D. G. Maggs, O. G. Kolterman, M. Chandran, S. R. Mudaliar, R. R. Henry, Impact of Pramlintide on Glucose Fluctuations and Postprandial Glucose, Glucagon, and Triglyceride Excursions Among Patients With Type 1 Diabetes Intensively Treated With Insulin Pumps Diabetes Care. ,vol. 26, pp. 1- 8 ,(2003) , 10.2337/DIACARE.26.1.1
Y. Lee, M.-Y. Wang, X. Q. Du, M. J. Charron, R. H. Unger, Glucagon Receptor Knockout Prevents Insulin-Deficient Type 1 Diabetes in Mice Diabetes. ,vol. 60, pp. 391- 397 ,(2011) , 10.2337/DB10-0426
Ansarullah, Yan Lu, Martha Holstein, Brittany DeRuyter, Alex Rabinovitch, Zhiguang Guo, Stimulating β-Cell Regeneration by Combining a GPR119 Agonist with a DPP-IV Inhibitor PLOS ONE. ,vol. 8, ,(2013) , 10.1371/JOURNAL.PONE.0053345
Mark A Atkinson, George S Eisenbarth, Type 1 diabetes: new perspectives on disease pathogenesis and treatment The Lancet. ,vol. 358, pp. 221- 229 ,(2001) , 10.1016/S0140-6736(01)05415-0
Jean-Philippe Fortin, Daniel Chinnapen, Martin Beinborn, Wayne Lencer, Alan S. Kopin, Discovery of dual-action membrane-anchored modulators of incretin receptors. PLOS ONE. ,vol. 6, ,(2011) , 10.1371/JOURNAL.PONE.0024693
Vikas K. Bhat, Barry D. Kerr, Peter R. Flatt, Victor A. Gault, A novel GIP-oxyntomodulin hybrid peptide acting through GIP, glucagon and GLP-1 receptors exhibits weight reducing and anti-diabetic properties Biochemical Pharmacology. ,vol. 85, pp. 1655- 1662 ,(2013) , 10.1016/J.BCP.2013.03.009