The Immunology of Xenotransplantation
作者： Christoph Knosalla , David K. C. Cooper
DOI: 10.1007/978-1-4471-0201-4_9
关键词:
摘要: Today, the shortage of organ donors is a major limiting factor to transplantation. In 1999 in USA, 72,110 patients were waiting for an transplant, while only 21,516 (16,862 cadaveric and 4,714 living) donor organs became available same year [1]. This results increasing times requiring kidney transplantation mortality greater than 10 percent per heart or liver For children, availability even more marked. These limitations, which show no immediate signs being resolved, have increased interest use xenogeneic organs. Xenotransplantation offers unlimited source cells, opportunity surgical procedure be performed on elective basis ability extend indications
springer.com
sci-hub.st 参考文章(30)
D. K. C. Cooper, S. Taniguchi, Clinical xenotransplantation: past, present and future. Annals of The Royal College of Surgeons of England. ,vol. 79, pp. 13- 19 ,(1997)
Kazuhiko Yamada, Akira Shimizu, Ryu Utsugi, Francesco L. Ierino, Patricio Gargollo, Gary W. Haller, Robert B. Colvin, David H. Sachs, Thymic Transplantation in Miniature Swine. II. Induction of Tolerance by Transplantation of Composite Thymokidneys to Thymectomized Recipients The Journal of Immunology. ,vol. 164, pp. 3079- 3086 ,(2000) , 10.4049/JIMMUNOL.164.6.3079
U Galili, S B Shohet, E Kobrin, C L Stults, B A Macher, Man, apes, and Old World monkeys differ from other mammals in the expression of alpha-galactosyl epitopes on nucleated cells. Journal of Biological Chemistry. ,vol. 263, pp. 17755- 17762 ,(1988) , 10.1016/S0021-9258(19)77900-9
Yong Zhao, Kirsten Swenson, Justin J. Sergio, J. Scott Arn, David H. Sachs, Megan Sykes, Skin graft tolerance across a discordant xenogeneic barrier Nature Medicine. ,vol. 2, pp. 1211- 1216 ,(1996) , 10.1038/NM1196-1211
Robert J. Perper, John S. Najarian, Experimental Renal Heterotransplantation: I. In Widely Divergent Species Transplantation. ,vol. 4, pp. 377- 388 ,(1966) , 10.1097/00007890-196607000-00002
Alex Zhu, Binding of human natural antibodies to nonalphaGal xenoantigens on porcine erythrocytes. Transplantation. ,vol. 69, pp. 2422- 2428 ,(2000) , 10.1097/00007890-200006150-00036
David H. Sachs, The pig as a potential xenograft donor Veterinary Immunology and Immunopathology. ,vol. 43, pp. 185- 191 ,(1994) , 10.1016/0165-2427(94)90135-X
Emanuele Cozzi, David J.G. White, The generation of transgenic pigs as potential organ donors for humans. Nature Medicine. ,vol. 1, pp. 964- 966 ,(1995) , 10.1038/NM0995-964
M. Basker, S. Gojo, A. Watts, S. Treter, K. Nash, G. Oravec, Q. Chang, A. Thall, J. D. Down, M. Sykes, D. Andrews, R. Sackstein, M. E. White-Scharf, D. H. Sachs, D. K. C. Cooper, High-dose porcine hematopoietic cell transplantation combined with CD40 ligand blockade in baboons prevents an induced anti-pig humoral response. Transplantation. ,vol. 69, pp. 2296- 2304 ,(2000) , 10.1097/00007890-200006150-00013
Denis Lambrigts, David H. Sachs, David K.C. Cooper, Discordant organ xenotransplantation in primates: world experience and current status. Transplantation. ,vol. 66, pp. 547- 561 ,(1998) , 10.1097/00007890-199809150-00001