Clinical features and outcomes of systemic amyloidosis with gastrointestinal involvement: a single-center experience.

摘要: Background/aims The gastrointestinal (GI) tract often becomes involved in patients with systemic amyloidosis. As few GI amyloidosis data have been reported, we describe the clinical features and outcomes of pathologically proven Methods We identified 155 diagnosed between April 1995 2013. Twenty-four (15.5%) were using associated symptoms, diagnoses confirmed by direct biopsy. Results Among 24 patients, 20 (83.3%) had light chain (AL), three (12.5%) amyloid A, one (4.2%) transthyretin-related type Their median age was 57 years (range, 37 to 72), 10 female (41.7%). most common symptoms diarrhea (11 45.8%), followed anorexia (nine 37.5%), weight loss, nausea and/or vomiting (seven 29.2%). histologically site AL stomach 11 (55.0%), colon nine (45.0%), rectum seven (35.0%), small bowel (5.0%). Patients involvement a greater frequency organ (p = 0.014). Median overall survival (OS) shorter (7.95 months; range, 0.3 40.54) than those without (15.84 0.0 114.53; p 0.069) univariate analysis. A multivariate analysis prognostic factors for revealed that not significant predictor OS 0.447). Conclusions prognosis poorer involvement, they presented more advanced disease involvement.