Changes in treatment patterns for patients with locally advanced rectal cancer in the United States over the past decade: An analysis from the National Cancer Data Base

摘要: BACKGROUND In the United States, neoadjuvant chemoradiotherapy (NACRT) is widely accepted as standard of care in treatment patients with locally advanced rectal cancer. In current study, authors attempted to examine patterns States over past decade. METHODS Using National Cancer Data Base, a total 66,197 who were diagnosed American Joint Committee on stage II III adenocarcinoma and treated between 2004 2012 identified. The described trends receipt for 3 time periods (2004-2006, 2007-2009, 2010-2012) analyzed 5-year overall survival probabilities 28,550 2007. RESULTS Receipt NACRT increased significantly from 42.9% 2006 50.0% 2007 2009, 55.0% 2010 (P < .0001). contrast, use adjuvant (CRT) decreased 16.7% 10.5% 6.7% Similarly, surgery alone 13.1% 8.7% Older age, presence comorbidities, larger primary tumor size, lymph node involvement, not being non-Hispanic white race/ethnicity, lack private insurance, at facility that did have high case volume associated lower possibility receiving NACRT. rates NACRT, CRT, alone, definitive CRT 72.4%, 70.9%, 44.9%, 48.8%, respectively. CONCLUSIONS The before US cancer has substantially decade. However, only approximately one-half currently receive this therapy, which could be explained part by socioeconomic factors. Trimodality therapy best outcomes these patients. 2016;122:1996–2003. © 2016 Society.