Breast Cancer

摘要: Rationale and Objectives Breast cancer is the leading cause of mortality in women worldwide. Lymphatic mapping with sentinel node biopsy has potential to reduce morbidity associated breast staging after neoadjuvant therapy. Materials Methods A systematic search world literature between 1996 2007 patients early-stage carcinoma chemotherapy was undertaken. Potentially eligible studies were identified using database-specific strategies incorporating appropriate Boolean combinations keywords or localization lymphatic mapping; malignancy neoplasm; preoperative chemotherapy. The electronic searches augmented a manual reference lists from articles. Successful lymph mapping, defined as successful identification rate (SIR), false-negative (FNR) summarized bivariate random effects mixed model. extent heterogeneity assessed inconsistency statistic. effect study level covariates, such use immunohistochemistry dual technique, individual quality criteria, design multi-institution participation, on SIR FNR analyzed metaregression. Results total 24 trials 1799 subjects reported that met eligibility criteria. All published 2000 2007. Lymph involvement found 758 (37%) ranged 25% 96% across studies. proportion who had 63% 100%, 79% reporting less than 95%. summary 0.896 (95% confidence interval [CI] 0.860–0.923) moderate heterogeneity. 0.084 CI 0.064–0.109) no significant Increasing prevalence same-day dissection both significantly reduced FNR. Conclusions present review demonstrates robust estimates rates therapy for patients. With 90% 8% FNR, this technique reliable tool planning treatment population an alternative completion axillary dissection.