No Evidence for Mouse Pancreatic β-Cell Epithelial-Mesenchymal Transition In Vitro
作者： F. Atouf , C. H. Park , K. Pechhold , M. Ta , Y. Choi
DOI: 10.2337/DB06-1446
关键词:
摘要: We used cre/loxP-based genetic lineage tracing analysis to test a previously proposed hypothesis that in vitro cultured adult pancreatic -cells undergo epithelial-mesenchymal transition (EMT) generate highly proliferative, differentiation-competent population of mesenchymal islet “progenitor” cells. Our results the mouse are likely be directly relevant human system show do not EMT and cells arise cultures pancreas derived from -cells. argue these most originate expansion integral heterogeneous preparations. As such, “progenitors” might represent best possible source for generation physiologically competent treatment diabetes. Diabetes 56:699 –702, 2007
diabetesjournals.org
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