Contribution of different scintigraphic techniques to the management of medullary thyroid carcinoma.

摘要: We compared three different scintigraphic techniques for the localization of neck recurrences and metastases in seven patients with medullary thyroid carcinoma one month to eight years after first surgical intervention. Three successive studies were performed five (6 x 3 studies) within two weeks using 201Tl chloride, 111In-labeled F(ab')2 fragments anti-carcinoembryonic antigen (anti-CEA) monoclonal antibody (MoAb) BW 431/31, 131I meta-iodo-benzylguanidine (MIBG). Additionally, 11 MoAb fragment 431/31 (seven or 99mTc-labeled intact anti-CEA 431/26 (four studies). The gold standards classifying results biopsy, histology, surgery, cytology. Six regions classified as positive negative each study: region, four quadrants (lymph node regions) around thyroid, region upper mediastinum. Of 36 sites, was true (TP) false-positive (FP) site, (TN) 22 false-negative (FN) six resulting a sensitivity 54% specificity 96%. MIBG TP FP none TN 23 FN nine 31% 100%. Immunoscintigraphy (102 sites overall) 16 77 80% 94%. 111In/99mTc fragment/intact is superior scintigraphy MIBG.