Major properties of dendritic cells and their actual and potential applications in cancer therapy and infectious disease prophylaxis

摘要: Dendritic cells are generally considered to be the most powerful and important among other antigen-presenting cells. Their major functions consist of capturing processing different microbial antigens subsequent activation naIve resting memory antigen-specific T There exist multiple dendritic cell subtypes expressing sets receptors, recognizing “danger signals” (lectins, receptors for constant fragments antibodies, Toll-like conserved pathogen-associated molecular patterns even natural killer targeting virus-infected or tumour cells). Due their variability functional plasticity, able execute including initiation immune reactions favourable protection against infectious agents induction tolerance towards self-antigens allergens. It is obvious that physiology should in design production new, more effective vaccines. Several methods generation vitro were developed. Vaccines based on such used successfully mice elicit protective T-cell immunity pathogens tumours. usefulness prevention treatment human diseases cancer currently under investigation.