CA125 and transvaginal ultrasound monitoring in high-risk women cannot prevent the diagnosis of advanced ovarian cancer

摘要: Abstract Objectives. The main objective of screening is to identify cases ovarian cancer in early stages. However, women the general population ineffective due a failure detecting early-stage disease and high false positive rates CA125 transvaginal ultrasound (TVU) monitoring. purpose this study evaluate by means pelvic examination, serum TVU consecutive series high-risk women. Methods. Clinical data were collected from 132 BRCA1, 20 BRCA2 germ line mutation carriers, 72 members hereditary breast (HBOC) families 88 patients (HBC) family, seen between January 1996 December 2002. Results. Among 10 with an elevated level TVU, three carcinomas (one FIGO stage IC, one IIIB IV) interval carcinoma (stage detected. Five occult ovarian/fallopian tube (two IA, after bilateral prophylactic (salpingo-) oophorectomy (BP(S)O) have been found 152 sensitivity, specificity, negative predictive values (PPV NPV) combination highest (40%, 99%, 40% 99%) followed alone (50%, 96%, 13% 99%), exam 98%, 21% separately 90%, 6% 99%). Conclusion. By combining results, PPV was achieved. diagnostic tools appear be only sensitive at advanced stage, while four tumors had normal tests prior diagnosis.