Advances in the development of hormonal modulators for the treatment of benign prostatic hyperplasia

摘要: Benign prostatic hyperplasia (BPH) is a leading disorder of the ageing male population and characterized by progressive enlargement prostate, resulting in obstruction proximal urethra hence disturbance normal urinary flow further quality life patients. Therefore, there an imperative need to develop therapeutic modality combat overgrowth prostate with improvements both rate At present, α-blockers, which act on dynamic component disease regulate increased adrenergic tone lower tract smooth muscles, 5-α-reductase inhibitors, control static regulating levels androgens, are mainstay therapies for treatment BPH associated symptoms. However, each target class has its own limitations terms compromised efficacy or tolerability. it i...