Multiple faces of dynamin-related protein 1 and its role in Alzheimer's disease pathogenesis

摘要: Mitochondria play a large role in neuronal function by constantly providing energy, particularly at synapses. Recent studies suggest that amyloid beta (Aβ) and phosphorylated tau interact with the mitochondrial fission protein, dynamin-related protein 1 (Drp1), causing excessive fragmentation of mitochondria leading to abnormal dynamics synaptic degeneration Alzheimer's disease (AD) neurons. research also revealed Aβ-induced tau-induced changes mitochondria, affecting shape, size, distribution axonal transport AD These affect health and, turn, could damage ultimately memory loss cognitive impairment patients AD. This article highlights recent findings Drp1 pathogenesis. its relationships glycogen synthase kinase 3, cyclin-dependent 5, p53, microRNAs