Robust continuous in vitro culture of the Plasmodium cynomolgi erythrocytic stages
作者： Adeline C. Y. Chua , Jessica Jie Ying Ong , Benoit Malleret , Rossarin Suwanarusk , Varakorn Kosaisavee
DOI: 10.1038/S41467-019-11332-4
关键词:
摘要: The ability to culture pathogenic organisms substantially enhances the quest for fundamental knowledge and development of vaccines drugs. Thus, elaboration a protocol in vitro cultivation erythrocytic stages Plasmodium falciparum revolutionized research on this important parasite. However, P. vivax, most widely distributed difficult treat malaria parasite, strict preference reticulocytes thwarts efforts maintain it vitro. Cultivation cynomolgi, macaque-infecting species phylogenetically close was briefly reported early 1980s, but not pursued further. Here, we define conditions under which cynomolgi can be adapted long term yield parasites that share many morphological phenotypic features vivax. We further validate potential system high-throughput screening prime accelerate anti-P. vivax drug discovery efforts.
nature.com
jenner.ac.uk
harvard.edu
archives-ouvertes.fr参考文章(63)
P. C. C. Garnham, A new subspecies of Plasmodiwm cynomolgi Rivista di Parassitologia. ,vol. 20, pp. 273- 278 ,(1959)
Alison Roth, Steven P. Maher, Amy J. Conway, Ratawan Ubalee, Victor Chaumeau, Chiara Andolina, Stephen A. Kaba, Amélie Vantaux, Malina A. Bakowski, Richard Thomson-Luque, Swamy Rakesh Adapa, Naresh Singh, Samantha J. Barnes, Caitlin A. Cooper, Mélanie Rouillier, Case W. McNamara, Sebastian A. Mikolajczak, Noah Sather, Benoît Witkowski, Brice Campo, Stefan H. I. Kappe, David E. Lanar, François Nosten, Silas Davidson, Rays H. Y. Jiang, Dennis E. Kyle, John H. Adams, A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum Nature Communications. ,vol. 9, pp. 1837- 1837 ,(2018) , 10.1038/S41467-018-04221-9
Trigg Pi, Recent advances in malaria parasite cultivation and their application to studies on host-parasite relationships: a review. Bulletin of The World Health Organization. ,vol. 63, pp. 387- 398 ,(1985)
Timothy N. C. Wells, Rob Hooft van Huijsduijnen, Wesley C. Van Voorhis, Malaria medicines: a glass half full? Nature Reviews Drug Discovery. ,vol. 14, pp. 424- 442 ,(2015) , 10.1038/NRD4573
Charles DiTusa, Michael P. Kozar, Brandon Pybus, Jason Sousa, Jonathan Berman, Montip Gettayacamin, Rawiwan Im-erbsin, Anchalee Tungtaeng, Colin Ohrt, Causal Prophylactic Efficacy of Primaquine, Tafenoquine, and Atovaquone-Proguanil Against Plasmodium cynomolgi in a Rhesus Monkey Model Journal of Parasitology. ,vol. 100, pp. 671- 673 ,(2014) , 10.1645/13-480.1
Beatriz Baragaña, Irene Hallyburton, Marcus C. S. Lee, Neil R. Norcross, Raffaella Grimaldi, Thomas D. Otto, William R. Proto, Andrew M. Blagborough, Stephan Meister, Grennady Wirjanata, Andrea Ruecker, Leanna M. Upton, Tara S. Abraham, Mariana J. Almeida, Anupam Pradhan, Achim Porzelle, María Santos Martínez, Judith M. Bolscher, Andrew Woodland, Torsten Luksch, Suzanne Norval, Fabio Zuccotto, John Thomas, Frederick Simeons, Laste Stojanovski, Maria Osuna-Cabello, Paddy M. Brock, Tom S. Churcher, Katarzyna A. Sala, Sara E. Zakutansky, María Belén Jiménez-Díaz, Laura Maria Sanz, Jennifer Riley, Rajshekhar Basak, Michael Campbell, Vicky M. Avery, Robert W. Sauerwein, Koen J. Dechering, Rintis Noviyanti, Brice Campo, Julie A. Frearson, Iñigo Angulo-Barturen, Santiago Ferrer-Bazaga, Francisco Javier Gamo, Paul G. Wyatt, Didier Leroy, Peter Siegl, Michael J. Delves, Dennis E. Kyle, Sergio Wittlin, Jutta Marfurt, Ric N. Price, Robert E. Sinden, Elizabeth A. Winzeler, Susan A. Charman, Lidiya Bebrevska, David W. Gray, Simon Campbell, Alan H. Fairlamb, Paul A. Willis, Julian C. Rayner, David A. Fidock, Kevin D. Read, Ian H. Gilbert, A novel multiple-stage antimalarial agent that inhibits protein synthesis Nature. ,vol. 522, pp. 315- 320 ,(2015) , 10.1038/NATURE14451
Rou Zhang, Rossarin Suwanarusk, Benoit Malleret, Brian M. Cooke, Francois Nosten, Yee-Ling Lau, Ming Dao, Chwee Teck Lim, Laurent Renia, Kevin Shyong Wei Tan, Bruce Russell, A Basis for Rapid Clearance of Circulating Ring-Stage Malaria Parasites by the Spiroindolone KAE609. The Journal of Infectious Diseases. ,vol. 213, pp. 100- 104 ,(2016) , 10.1093/INFDIS/JIV358
W Trager, J. Jensen, Human malaria parasites in continuous culture Science. ,vol. 193, pp. 673- 675 ,(1976) , 10.1126/SCIENCE.781840
Yan Quan Lee, Amanda S. P. Goh, Jun Hong Ch'ng, François H. Nosten, Peter Rainer Preiser, Shazib Pervaiz, Sanjiv Kumar Yadav, Kevin S. W. Tan, A High-Content Phenotypic Screen Reveals the Disruptive Potency of Quinacrine and 3′,4′-Dichlorobenzamil on the Digestive Vacuole of Plasmodium falciparum Antimicrobial Agents and Chemotherapy. ,vol. 58, pp. 550- 558 ,(2014) , 10.1128/AAC.01441-13
Ji-Hu Zhang, Thomas D. Y. Chung, Kevin R. Oldenburg, A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. Journal of Biomolecular Screening. ,vol. 4, pp. 67- 73 ,(1999) , 10.1177/108705719900400206