Systemic postganglionic adrenergic studies do not distinguish Parkinson's disease from multiple system atrophy.
作者： Axel Lipp , Paola Sandroni , Phillip A. Low
DOI: 10.1016/J.JNS.2009.03.006
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摘要: Abstract Background Multiple system atrophy (MSA) affects the preganglionic adrenergic neuron and Parkinson's disease (PD) involves postganglionic counterpart. Widespread denervation should result in supersensitivity a failure of axon to release norepinephrine (NE). We examined if pharmacological dissection can distinguish between MSA PD. Method measured blood pressure, heart rate, plasma NE responses direct (phenylephrine) indirect (tyramine) acting agonists 15 patients with probable MSA, 16 idiopathic PD, age- gender-matched controls. Results Baroreflex sensitivity was impaired intact Pressor phenylephrine (direct acting) were higher ( p = 0.04) than Blood pressure tyramine (indirect increased only Conclusion There is PD that is, however, insufficient shift dose-response curve left. The excessive pressor both are due baroreflex failure. conclude this diagnostic approach lacks sufficient differentiate MSA.
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