Desensitization in ABO-Incompatible Kidney Transplantation With Low ABO Iso-Agglutinin Titers.

摘要: Abstract Background In ABO-incompatible (ABOi) kidney transplantation (KT) with low iso-agglutinin (IG) titers (IGT), standard pre-conditioning treatment might be excessive. To try to answer this question, we evaluated the requirements of a group ABOi KT ABO IGT in our center. Our main objective was assess desensitization for ( Methods A retrospective study (rituximab and plasma exchange [PE]) IGT  Results One 5 years after KT, patient survival 100%. Renal graft 90% at 1 KT. Mean PE performed before 1.7 (standard deviation [SD], 1.703); 50% patients did not receive transplantation, 30% received 2 sessions PE, 20% only 1. The average is 0.8 (SD, 0.91).Follow-up IG determinations remained (≤8/8). No rebounds were observed during first 4 6 months transplantation. Conclusions Recipients IGT ≤8 required none or session reach acceptable (titers ≤4) perform safely. This information useful possibility minimized protocol donors reduce adverse effects, cost, simplify pre-transplant logistics.