II, 10. The rat model of rotavirus infection

摘要: Publisher Summary Rotaviruses (RVs) are ubiquitous and virtually 100% of the adult population has antibody to RV. Understanding RV infection immunity in humans is important, but studies difficult because inability control for many experimental variables, such as prior exposure virus. As an alternative, animal model systems have been developed provided key insights understanding infection, pathogenesis, both human RVs. Seven models four large (cow, pig, horse, sheep) three small laboratory (rabbit, mouse, rat) species used define parameters pathology, disease, immune response or test vaccine efficacy. This chapter describes rat infection. The was only fully recently spite ideal size intestine physiological including Ussing chamber analysis, well-established physiology gastrointestinal tract rats, cost effectiveness use rats perform experiments. unique among it allows infections be analyzed.