Systems and methods for reducing or preventing backflow in a delivery system

摘要: Systems and methods are disclosed herein that generally involve CED devices with various features for reducing or preventing backflow. In some embodiments, include a tissue-receiving space disposed proximal to distal fluid outlet. Tissue can be compressed into pinched/pinned by the as device is inserted target region of patient, thereby forming seal reduces prevents backflow ejected from outlet beyond space. bullet-shaped nose The forms good surrounding tissue helps reduce prevent infused fluid.