Distribution of coenzyme Q homologues in brain.
作者： C. B. Albano , D. Muralikrishnan , M. Ebadi
关键词:
摘要: Ubiquinone (coenzyme Q10), in addition to its function as an electron and proton carrier mitochondrial transport coupled ATP synthesis, acts reduced form (ubiquinol) antioxidant, inhibiting lipid peroxidation biological membranes protecting inner-membrane proteins DNA against oxidative damage accompanying peroxidation. Tissue ubiquinone levels are subject regulation by physiological factors that related the activity of organism: they increase under influence stress, e.g. physical exercise, cold adaptation, thyroid hormone treatment, decrease during aging. In present study, coenzyme Q homologues were separated quantified brains mice, rats, rabbits, chickens using high-performance liquid chromatography. addition, measured cells such NG-108, PC-12, rat fetal brain human SHSY-5Y monocytes. general, Q1 content was lowest among brain. Q9 not detectable but rats mice. also detected cell lines Q10 lines. Since both vitamin E antioxidants, recycles vitamins C, mice HPLC-electrochemical detector (ECD). The quantity substantia nigra compared with other regions. This finding is crucial elucidating bioenergetics; preventing free radical generation, peroxidation, apoptosis brain; a potential compound treating various neurodegenerative disorders.
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sci-hub.se 参考文章(33)
A. Kröger, Determination of contents and redox states of ubiquinone and menaquinone. Methods in Enzymology. ,vol. 53, pp. 579- 591 ,(1978) , 10.1016/S0076-6879(78)53059-0
Coenzyme Q : Molecular Mechanisms in Health and Disease CRC Press. ,(2000) , 10.1201/9781420036701
Gustav Dallner, Gustav Dallner, Yiyi Zhang, Eeva-Liisa Appelkvist, Fredrik Åberg, Lars Ernster, Uptake of Dietary Coenzyme Q Supplement is Limited in Rats Journal of Nutrition. ,vol. 125, pp. 446- 453 ,(1995) , 10.1093/JN/125.3.446
C.J.G. Lang, H. Sittl, F. Erbguth, Coenzyme Q10 treatment in mitochondrial encephalomyopathies : Short-term double-blind, crossover study European Neurology. ,vol. 37, pp. 212- 218 ,(1997) , 10.1159/000117445
Stephen E. Farinelli, Lloyd A. Greene, Wilma J. Friedman, Neuroprotective actions of dipyridamole on cultured CNS neurons The Journal of Neuroscience. ,vol. 18, pp. 5112- 5123 ,(1998) , 10.1523/JNEUROSCI.18-14-05112.1998
S. Ogasahara, A. G. Engel, D. Frens, D. Mack, Muscle coenzyme Q deficiency in familial mitochondrial encephalomyopathy Proceedings of the National Academy of Sciences of the United States of America. ,vol. 86, pp. 2379- 2382 ,(1989) , 10.1073/PNAS.86.7.2379
Andrew Chan, H. Reichmann, Anke Kögel, Andreas Beck, R. Gold, Metabolic changes in patients with mitochondrial myopathies and effects of coenzyme Q10 therapy. Journal of Neurology. ,vol. 245, pp. 681- 685 ,(1998) , 10.1007/S004150050267
G.T. Vatassery, C.K. Angerhofer, C.A. Knox, D.S. Deshmukh, Concentrations of vitamin E in various neuroanatomical regions and subcellular fractions, and the uptake of vitamin e by specific areas, of rat brain Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. ,vol. 792, pp. 118- 122 ,(1984) , 10.1016/0005-2760(84)90211-X
Robert P Ostrowski, Effect of coenzyme Q10 on biochemical and morphological changes in experimental ischemia in the rat brain Brain Research Bulletin. ,vol. 53, pp. 399- 407 ,(2000) , 10.1016/S0361-9230(00)00406-8
Ching K Chow, Wissam Ibrahim, Zhihua Wei, Alvin C Chan, Vitamin E regulates mitochondrial hydrogen peroxide generation. Free Radical Biology and Medicine. ,vol. 27, pp. 580- 587 ,(1999) , 10.1016/S0891-5849(99)00121-5